Breakpoints for a component are saved automatically. They can be disabled using the context menu:

Disabled breakpoints are shown with a grey background.
The Breakpoints tab lists all breakpoints in all components that currently have a breakpoint defined.

To disable a breakpoin uncheck its checkbox.
The toolbar buttons support the following:
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Delete a selected breakpoint. |
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Clear all breakpoints in the open application. |
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Enable or disabled selected breakpoints in the Source view. |
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Display the selected statement in the Source view. |
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Display the Breakpoint Properties dialog. |